Fuel

by Vivienne Baillie Gerritsen

We need fat. From bacteria and yeast to petunias, goldfish and humans, every single action an organism performs, whether conscious or not, requires some sort of fuel. Budding, photosynthesis, predation, digestion, hibernation, seeing, thinking, eating, breathing, immunity, sleeping, swimming, walking - the list is far too long to draw. Not everything works on fat, of course. Sugars and adenosine triphosphate (ATP) are also extensively used. It all depends on the metabolism and the biochemistry involved. The fact is, organisms are in constant need of energy, which is why they store it continuously. Triacyglyerol (TAG) is the main form of fat stored by animals and plants, and adipocytes are specifically dedicated to its accumulation. Within adipocytes, as is the case for most eukaryotic cells, TAG is confined to intracellular specialised bodies known as lipid droplets (LDs). Though ignored for years, more and more attention is being given to LDs. Once considered mere globs of fat, LDs have now been promoted to the status of full-blown organelles with their own dynamics. Lately, scientists discovered a protein intricately involved in their genesis and growth. They called it adipogenin.

Protein Spotlight (ISSN 1424-4721) is a monthly review written by the Swiss-Prot team of the SIB Swiss Institute of Bioinformatics. Spotlight articles describe a specific protein or family of proteins on an informal tone. Follow us: Subscribe · Facebook · Linkedin

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LIFE, LOVE, DEATH & PROTEINS

La vie etc. cover

"La vie, l'amour, la mort & les protéines" (in French only) is a wonderful and unique collection of twenty comic strips created with cartoonist aloys lolo. Each comic describes one protein taken from the Protein Spotlight articles. The album was published in November 2023 by Antipodes, Switzerland. Order your copy online. English version online here.

Snapshot : Titin

Senora Pilasana
Voulez-vous le taximeter?
Le tionta su la seata
Tu la tu la tu la wa
This is gibberish sung by Charlie Chaplin in ‘Modern Times’ as he struggles to satisfy an impatient audience whilst frantically seeking for his cuff – on which he had written the true lyrics – which had flown off his wrist following an unfortunate flick as he made a hasty entry to perform. He ad-libs novel lyrics to the tune of ‘Je cherche après Titine’ (‘Looking for Titine’) a then popular French song written by M.Bertal and L.Maubon in 1917, the music of which was composed by L.Daniderff. As a result, Chaplin not only added to the song’s popularity but also made it worldwide. Little did he know though that what helped him to dash around the dining-room as he searched for the lost cuff is also named…titin….

A little bit of praise!

“I recently stumbled upon your columns. Let me congratulate you on achieving the near impossible, for your articles have enabled me to successfully marry IT with the Life Sciences and better explain the concepts of bioinformatics to those who are not in the know of the field.

Your articles are very well written, lucid, and contain just enough information to excite the reader to want to learn more about the topic being discussed. They fall in a very rare category where they are accessible to everyone, from the undergraduate students to research students who want to have a basic idea of the topics being discussed. Some of your articles, like "Our hollow architecture" and "Throb" are outstanding pieces.

I would highly recommend your articles as a necessary reading in undergrad classes to get students inspired about the various avenues of research.”

— Rohan Chaubal, Senior Researcher in Genomics

Thank you to Fania Simon whose work we reproduce on our site!